Abstract: 200 patients were studied during January 2013 to December 2014. Complete history, total serum calcium levels, lipid profile were measured to evaluate patient. 121 were males and 79 were females the ages of 45 and 65 years. We used linear regression model. Our variable were age, calcium, body mass index, cholesterol, HDL cholesterol, triglycerides and covariate were systolic and diastolic blood pressure, and pulse. Serum calcium was associated with systolic and diastolic blood pressure, serum cholesterol, serum triglyceride and HDL cholesterol in both sexes (P<0.001). Serum calcium levels were higher in men with a history of myocardial infarction than in those without in all age group (P<0.0001). Serum calcium level was independent risk factor for Myocardial Infarction when all the other variables were also included (P<0.0001).