Abstract: A total number of 402 infertile males aged between 25 and 50 were studied for the presence of antisperm antibodies (ASA) in their blood. They were grouped together basing on their occupation and the nature of their work, which included drivers, business men, gold smith Industrial workers and teachers. Prevalence of ASA among these groups was studied and the results were analyzed. It was observed that the formation of ASA was associated with the temperament of the individual and the environment of occupation. Stress, tension pollution reduced physical activity and occupational temperature ware directly proportional. Stress associated personal habits like smoking and alcoholism were found to be related factors. Further 85% of the infertile men with obesity showed ASA positivity.