Abstract: In Kenya, the newly promulgated constitution of 2010 (CoK, 2010), provides the basis of monitoring and evaluation as an important tool for operationalizing Government projects to ensure transparency, integrity and accountability. The study was conducted in six Lake Region economic Bloc Counties namely, Migori, Homabay, Kisumu, Siaya, Kakamega and Vihiga. This study specifically assessed the effectiveness of Monitoring and Evaluation Structure on the Performance of County Governments. The study was guided by the change and structural functionalism theories advanced by Emile Durkheim.