Abstract: Since, the onset of the COVID-19, leads the fear for the impulsive buying of several instruments / devices / accessories based on the ultraviolent radiation which can help in preventive and / or therapeutic measures in the current pandemic. This leads to the huge cash inflow in this sector but without enough return in term of effectiveness and curability. In this review, peer reviewed papers are reviewed regarding the disinfecting and therapeutic behavior of various techniques, devices and procedures in various spectral wavelength, i.e. infrared, visible and ultraviolent already in use against the microbial, viruses and fungi. This will help the general public and health care professional to optimize their vision for the photo / radiation based devices on the concrete scientific evidence / knowledge rather than on the market’s trend of making ultraviolent radiation as the ultimate solution.