Abstract: This study aimed to evaluate the possible ameliorative effect of ellagic acid, and rosemarinic acid on doxorubicin-induced cardiotoxicity and nephrotoxicity in rats. Therefore, male Sprague Dawley rats were divided into eight groups, control group, ellagic acid (10mg/kg, p.o.) group, rosemarinic acid (75mg/kg, p.o.) group, combined ellagic and rosemarinic acid for 14 days. Cardio-nephrotoxicity was induced by doxorubicin injection (5mg/kg, i.p.) every 3 days. Doxorubicin administration started on the fourth day of ellagic or/and rosemarinic acids treatment. Animals were scarified on 15th day.