IJSRP, Volume 6, Issue 2, February 2016 Edition [ISSN 2250-3153]
Omar W. Maher, Raslan Y.A, Amany A.E. Ahmed, Eman M. Raafat, Gehan S. Georgy
This study aimed to evaluate the possible ameliorative effect of ellagic acid, and rosemarinic acid on doxorubicin-induced cardiotoxicity and nephrotoxicity in rats. Therefore, male Sprague Dawley rats were divided into eight groups, control group, ellagic acid (10mg/kg, p.o.) group, rosemarinic acid (75mg/kg, p.o.) group, combined ellagic and rosemarinic acid for 14 days. Cardio-nephrotoxicity was induced by doxorubicin injection (5mg/kg, i.p.) every 3 days. Doxorubicin administration started on the fourth day of ellagic or/and rosemarinic acids treatment. Animals were scarified on 15th day.