International Journal of Scientific and Research Publications

IJSRP, Volume 6, Issue 2, February 2016 Edition [ISSN 2250-3153]


The Ameliorative Effect of Ellagic Acid and Rosemarinic Acid against Cardio-nephrotoxicity Induced by Doxorubicin in Rats
      Omar W. Maher, Raslan Y.A, Amany A.E. Ahmed, Eman M. Raafat, Gehan S. Georgy
Abstract: This study aimed to evaluate the possible ameliorative effect of ellagic acid, and rosemarinic acid on doxorubicin-induced cardiotoxicity and nephrotoxicity in rats. Therefore, male Sprague Dawley rats were divided into eight groups, control group, ellagic acid (10mg/kg, p.o.) group, rosemarinic acid (75mg/kg, p.o.) group, combined ellagic and rosemarinic acid for 14 days. Cardio-nephrotoxicity was induced by doxorubicin injection (5mg/kg, i.p.) every 3 days. Doxorubicin administration started on the fourth day of ellagic or/and rosemarinic acids treatment. Animals were scarified on 15th day.

Reference this Research Paper (copy & paste below code):

Omar W. Maher, Raslan Y.A, Amany A.E. Ahmed, Eman M. Raafat, Gehan S. Georgy (2018); The Ameliorative Effect of Ellagic Acid and Rosemarinic Acid against Cardio-nephrotoxicity Induced by Doxorubicin in Rats; Int J Sci Res Publ 6(2) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0216.php?rp=P505102
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