Abstract: The synthesis of benzothiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. The structural formula of all derivatives was confirmed and characterized by elemental analysis and spectral studies. A methanol extract of Pongamia pinnata, Syzigium cumini, Delonix regia, Adathoda zeylanica was done by Soxhlet. The combinations of the plant extracts with the organic compounds were evaluated for anti-inflammatory, anti-oxidant activity and checked for their cytotoxicity. Our findings indicate that the plant extract and organic compounds have a significant effect on biological evaluations.