Abstract: A number of benzothiazole-2-ylsulfanyl derivatives 2-(1,3-Benzothiazol-2-ylsulfanyl)alkanoylhydrazide (IA – IG) and 5-[1-(1,3-Benzothiazol-2-ylsulfanyl)alkyl]-1,3,4-thiadiazole-2-(3H) thione (IIA-IIG) have been synthesised from (1,3-Benzothiazol-2-ylsulfanyl)acetic acid. These compounds were synthesied and characterized from their F.T.I.R, and H-NMR spectral studies. The compound (IIA to IIG) were screened for antibacterial activity and antifungal properties. The compound 2A-2G showed appreciable antifungal and antibacterial activity.