Abstract: Epididymis play a very important role in the male reproduction. It is also the job of the epididymis to bring the sperms to maturity since the sperms that emerge from the testes are immature and incapable of fertilization. Contraceptive efficacy of C. papaya seed extracts have also been well documented in various animal models. This study examines the effect of oral administration of ethanol extract ofC. papaya seeds on the histology of epididymis of the adult male albino mice. 60 healthy adult male albino mice were divided into 4 Groups (Group I to IV) of 15 mice each. 50 and 70 mg/kg/day of the extract were orally administered to Groups II and III respectively while Group I served as placebo (control). The daily administration was carried out for a period of 45 days after which the animals of Group I ,II and III were sacrificed. The epididymis were obtained and processed for light microscopy.