Abstract: Metabolic disorders including thyroid dysfunction is increasing problem throughout the world. We aim to observe the pattern of thyroid disorder among people attending one of the hospitals in the central development region of Nepal. An observational study was conducted among 290 individuals who attended the Medical unit of Shree Puspanjali Hospital Pvt. Ltd, Bharatpur-10, Nepal between May 2016 and August 2016. Socio-demographic characteristics, clinical characteristics and laboratory data (from thyroid function test) were collected. Data were analyzed using IBM-SPSS 20.0 and descriptive and inferential analysis was performed. Of the 290 individuals, 215 (74.23%) had thyroid disorders among which hypothyroidism was the most common disorder (187, 87.0%) followed by hyperthyroidism (24, 11.2%) and subclinical hypothyroidism (4, 1.9%). Majorities (261, 90%) of the participants were female and so were those with thyroid disorders (196, 91.2%). The mean age of the participating individuals was 45.9±1.3 years. Hypertension (49, 16.9%) was the commonest co-morbid condition among the participants (30, 10.3%) but diabetes (p=0.004) and dyslipidemia (p=0.002) were significantly associated with thyroid disorder. In conclusion, hypothyroidism was the most common thyroid disorders and female were at the most vulnerable group. This is a single hospital based study; therefore, it is not sufficient to generalize the thyroid disorder in whole population.