Abstract: Now a days Automated Systems are widely adapted for most modern industries. Data acquisition is the major component of any automation system. The robustness of the automation system mainly depends on the accuracy and speed of the data acquired from Data Acquisition System(DAS). This paper mainly focusses on the design of high accurate multi-channel Data Acquisition System for real time automation applications. Data acquisition is used to acquire data from sensors and other sources under computer control and bring the data from different channels together to store and manipulate it. The sensors may include thermocouples, voltage and current sensors to make variety of measurements from different remote locations in the industries. The proposed method can sense all the 48 channels data in two seconds. The filters used in the application makes the acquired data to be more accurate with accuracy level of 30 PPM.