Abstract: Adiponectin is an adipocyte-derived peptide that acts as a hormone with anti-inflammatory and insulin-sensitizing properties. Lower serum levels of adiponectin have been consistently associated with increased risk of type 2 diabetes in numerous prospective studies of diverse nationalities. However, few studies among Filipinos were documented. The objective of this study is to identify if adiponectin could serve as a biomarker of type 2 diabetes mellitus among Filipino respondents by determining the association of its levels with the presence of impaired fasting blood glucose, type 2 diabetes mellitus, insulin resistance and other anthropometric parameters. This study, conducted in University of Santo Tomas Hospital-Out Patient Department, compared the levels of adiponectin in normal, pre-diabetic and diabetic groups, with each having 28 randomly selected samples and equivalent gender ratio. Blood samples were analyzed for fasting blood glucose (FBS), insulin and adiponectin.