Abstract: A stability indicating high performance liquid chromatography (HPLC) method is developed for the quantification of salicylic acid (SA) and Tolnaftate (TF) in combined pharmaceutical ointment base formulations. The separation was performed on a Merck” C-18 column with the mobile phase consisting of Acetonitrile: Methanol: Water (50:20:30v/v) at flow rate 1.5ml/min. Both the drugs were resolved successfully with retention time 1.318 and 8.805minute when detection was carried out at UV 245nm.The overall retention time of analytes were 10.0minutes.The method was validated with respect to linearity, precision, accuracy and recovery. The relative standard deviation for six replicate measurements of SA and TF were 0.259% and 0.240% respectively. Total recoveries of analytes were 100.56, 100.63, 100.58% and 100.23, 100.73, 100.22% of SA and TF respectively when examine over the range of 80, 100, and 120% of added drugs in placebo.