Abstract: Energy from subsurface of earth at specific location that has ability to change the normal functioning of human system is called as Geopathic Stress. Suitability of the site in ancient times is carried out by different tests (Bhumi Pariksha), architectures and civil engineers were very particular in selecting the site for dwelling but in recent past geopathic stress is rarely considered spatial planning. Recent studies have shown that it is one of the causes for inception of disease. Places on road affected by this stress are prone to accidents. This paper highlights about the significance and need of considering Geopathic stress as one of the parameter for spatial planning. Research shows that the Geopathic stress from nadir direction changes the reaction time of the driver which in turn leads to road accidents. Thus, by considering the aspect of Geopathic stress for planning, a safe and sustainable development of infrastructure will of benefit to the mankind.