Abstract: Rice (Oryza sativa) is an important food crop of India and the world, is frequently attacked by pathogens like bacteria, fungi, viruses, pests and weeds. These diseases reduce both quantity and quality of plant products. In this present investigation unique Gram positive pathogenic bacteria, Bacillus cereus (as identified by NCBI BLAST)along with fungal spores of Bipolaris sp pathogens shared the same leaves of Lal Swarna variety of rice and showed dark brown spots with yellow halo on leaves. Here, Bacillus cereus which maximum sensitive to Sulbactam and least to Ceftadime was not a pathogen of rice before and it is first time observed as a pathogen of rice and at the same time it shows antagonism with Bipolaris sp. growth. This investigation also shown this mixed infection resulted in less vigorous infection of Bipolaris to this rice plant and which can be utilized in biological control in place of pesticides.