Abstract: Woman entrepreneurship development, especially among women largely focuses on the empowerment of women through developing skills in small to medium-sized enterprise (SME) and business ventures by taking risk of making investment decisions. This study reveals various aspects of woman entrepreneurs of SMEs. The opportunities and challenges faced by the woman entrepreneurs of SMEs in Rajshahi area is the main focus of the article. The study finds out the role of woman entrepreneurs of SMEs, various SME industries for woman entrepreneurs, financial and technical aids for the women, problems faced by entrepreneurial activities and opportunities to increase entrepreneurial skills among the woman entrepreneurs as well as it recommends suggestions as well. The study has some sort of limitations.