Abstract: The study was aimed at ascertaining the prevalence of typhoid fever by Salmonella typhii and the four year trend of the infection in Etinan, Akwa Ibom State using hospital-based data. Hospital records of those who attended the General Hospital Etinan for medical attention was collected and collated. The four year cumulative prevalence of Salmonella infection was 63.8% (58.0% for males and 68.2% for females), Prevalence was significantly higher among females than among males (x2-test; p < 0.05). Prevalence was comparable in all the years except for the year 2001, which had a significantly higher prevalence than that of each of the other years (x2-test; p < 0.05 for all the tests). A comparison of the prevalence of Salmonella typhi in each of the age groups between 2000 and 2003 showed that in 2001, there was significantly high prevalence (up to 80%) in the first two age groups, 0-4 years and 5-9 years, unlike in the other years where prevalence in the same age groups ranged from 12% to 52% (x2-test; p < 0.05 for all the tests). Generally, prevalence among the various age groups ranged from: 12% in 0-4 years age