IJSRP, Volume 11, Issue 6, June 2021 Edition [ISSN 2250-3153]
Megawati Tambunan, Ibnu Alferraly, Lidya Imelda Laksmi
Thyroid carcinoma is malignancy in thyroid gland showing differentiation of epithelial cells, namely follicular or parafolicular cells. Papillary thyroid carcinoma (PTC) is a thyroid carcinoma that is most often found in about 80% of all thyroid carcinomas. ERα contributes to tumor growth primarily by stimulating aberrant cell proliferation and inhibiting cell apoptosis, whereas ERβ suppresses tumorigenesis through cell proliferation, maintains cell differentiation and induces apoptosis. Based on contradictory nature of ERα and ERβ contradictory and several studies linking ER expression with PTC have conflicting results, the researchers are interested in assessing the relationship between ERα and ERβ immunohistochemical expression in PTC. Objective: To analyse the relationship between ERα and ERβ immunohistochemical expression in PTC.