Tuberculosis clients are experiencing various problems in terms of adaptation models such as physical problems, psychological problems, social problems and problems of dependence.This study is a correlational study. The method used is a cross-sectional. Respondents in this study were taken was 83 clients at the Lung Hospital in Jember. This research measurement is using a questionnaire. This study uses path analysis technique. Analysis of the data on the effect of the stimulus to coping witht-statistic = 2.370. Analysis the effect of the stimulus to adaptation with t-statistic = 2.115. Analysis the effect of the coping mechanisms to adaptation with t-statistic = 2.348. Stimulus contributes significantly to the coping mechanisms, stimulus significantly contributes to the adaptation, and coping mechanisms significantly contribute to the adaptation of Tuberculosis clients during treatment at the Lung Hospital in Jember.Education and socialization about tuberculosis and peer group of tuberculosis clients in community are significantly needed to increased tuberculosis client adaptation. Suggestions for further research, collecting data by using prospective observation is better than retrospective observation.