Abstract: The aim of this paper is to examine the relationship between economic environment (inflation rates and interest rates were used as the dimensions) and organizational performance (the measures used was profitability) of manufacturing firms in Rivers State, Nigeria. We therefore adopted quasi experimental design in the form of cross-sectional research survey design and our population was 48 manufacturing firms gotten from Manufacturers’ Association of Nigeria, Rivers State Chapter and the sample size was 44 using the Krejcie and Morgan (1970) sample size determination table; also, simple random sampling technique was used and the research instrument. Data was collected through questionnaire as the research instrument which was analyzed using spearman’s rank order correlation coefficient with the aid of Statistical Package for Social Sciences. Our findings revealed that inflation rates and interest rates significantly influence profitability respectively, thus we concluded that economic environment significantly influence organizational performance.