Abstract: Open fractures are common problems in orthopedic practice that requires immediate management and intervention because of the high incidence of complications. This study presented the initial report after piloting of the clinical pathway to compare the efficacy of using clinical pathway versus nonclinical pathway in the management of open fracture of the long bone in a tertiary hospital. Specifically, this study aimed to determine a) the clinical profile of the patients in the pathway in terms of age, sex, mechanism of injury and type of open fracture based on the Gustilo-Anderson classification; b) determine the time interval from the initial consult at the emergency department to admission, time interval from admission to operative procedure, time interval from admission to discharge, the rate infection or need for repeat surgery related to infection and the clinical and statistical significance of the variables between the clinical pathway group vs non-pathway group.