Abstract: Cardiopulmonary resuscitation (CPR) and defibrillation are the interventions performed by health care professionals in order to preserve the life of a patient suffering cardiac arrest. These tasks are important to the role of nurses because they are the most common first responders to in-hospital cardiac arrest scenarios. The early initiation of CPR and defibrillation is essential in increasing the likelihood of a patient surviving cardiac arrest. The aim of the study is to assess factors influencing nurses’ initiation of cardio-pulmonary resuscitation among in-hospital cardiac arrest patients in selected hospitals of Kano State Metropolis. A mixed method design was used for the study.