Abstract: Canine parvovirus infection is serious life threatening infectious viral disease and major cause of death in young puppies. Due to lack of proper vaccination , mismanagement and lack of knowledge about proper vaccination schedule to pet owners are key cause of occurrence of canine parvo viral disease in Nepal. The disease occurs in two form intestinal and cardiac form in which occurrence of intestinal form is higher with hemorrhagic enteritis. The German shepherd dog of 6 months old was presented at Central Referral Veterinary Hospital (CRVH). The dog was suffering from anorexia , vomiting , bloody diarrhea , dehydration and subnormal temperature .