Abstract: As medicinal science heading towards the new discoveries, butthe trap of psychological disorders, kept questioning about the capabilities of medicinal science. They sinisterly kill people through their slow poisons like dementia, depression as well as in form different diseases like Schizophrenia, Alzheimer, Autism, Parkinson and many others. In our study we focused on analysis of two totally different diseases that are Alzheimer and Autism. Former one affect the old stage while later shows its presence in childhood stage of us Homo sapiens life. Many neurotransmitters, proteins and various chemicals play their different roles in these two disorders. But certainly Dopamine which is a monoamine synthesized from amino acid tyrosine is a common neurotransmitter play its vital role by varying its percentage in these two diseases. Due to dopamines soluble nature, in case of Alzheimer aggregates with beta-peptide while in Autisms case it affect the central nervous system (CNS). In between huge number of genes of Dopamine, we selected the Dopamine beta hydroxylase gene, which help in combining the study of Alzheimer and Autism together, using different Bioinformatics tools, and proteomic and gene expression analysis. On such basis, among Bos tarus, Rattus norvegicus, Mus musculus, Canis lupus, Danio rerio, Homo sapiens and Equus caballus, we determined the best model organism for Alzheimer and Autism and which may help in future aspects of pharmacogenomics & personalized medicines for both.