Abstract: Mycoplasma pneumoniae (MP) is a common pathogen in cases of atypical pneumonia. Most individuals with Mycoplasma pneumonia run a benign course, with non-specific symptoms of malaise, fever and non-productive cough that usually resolve with no long-term sequelae. Multi organ dysfunction is not commonly seen in Mycoplasma pneumonia infection. We, report a case of Mycoplasma pneumonia complicated with multiple organ failure in a previously healthy woman. She had severe hemolysis, acute respiratory distress syndrome and acute renal failure. She had complete recovery with intensive management in an intensive care unit.