Abstract: Background: Low back pain (LBP) is a global health issue and the largest contributor to disability affecting about 80% of people during their lifetime and some will develop into Chronic Low Back Pain (CLBP). Low back pain also causes mental health problems such as stress, anxiety, and depression. The most common mental health problems associated with low back pain are symptoms of depression. Considering that there is still a lack of awareness of mental disorders that cause an increase in the number of cases of depression in low back pain patients, this present study is to investigate factors related to the development of depressive symptoms in low back pain. 97 samples of patients with low back pain were obtained in this study. Multiple linear regression was then used to assess relationships of independent risk factors to depressive symptoms score. The final multivariate result in the model that fit the factors associated with depression in low back pain patients were age with p value = 0.012 and r value = -0.152, monthly income with p < 0.001 and r value = -0.473, duration of disease with p value < 0.001 and r value = 0.233 were found to contribute to depressive symptom scores for as much as 73.5%. Age, monthly income, duration of disease, are contributing factors related to depressive symptom score among low back pain patients.