Abstract: Using quantum hydrodynamic (QHD) model, a comprehensive investigation of propagation of longitudinal acousto-electric wave in colloids laden semiconductor plasmas is presented. It is noticed that the Bohm potential in the wave spectrum of the semiconductor plasma enhances the gain and also modifies the amplification characteristics of sound wave for both cases in which colloidal particles are either stationary (0d = 0) or streaming (0d ≠ 0). The result of this investigation would be useful in understanding the characteristics of longitudinal electro-acoustic wave in magnetized n-type piezoelectric semiconductor quantum plasma and would be helpful in the fabrication of acousto-electric devices.