Abstract: The aim of this study was to assess the attitude and perception of female students towards Mathematics and determine the relationship of attitude to mathematics and career aspiration of female students. Four hundred and twenty five (425) SSII and SSIII students participated in the research. Questionnaire was used for data collection and the data collected was subjected to statistical analyses in SPSS using frequency, percentage, Pearson correlation and bivariate t test. A very weak positive correlation between female career aspiration and female students’ attitude to mathematics was observed (r = 0.004, p > 0.01). The results also revealed significant difference in the female attitude to mathematics and female career aspiration (t = 52.572, df = 424, p < 0.01). The aspiration of female students into Science and Technology was very low.