Abstract: Water-logging is one of the major environmental problems and challenges of socio-economic development in the south-western part of Bangladesh. In this research paper, Jessore district of Khulna division was selected as the study area to detect water-logging and damaged agriculture lands. To carry out this detection, Landsat imageries from 1972, 1989 and 2014 were used. A post classification comparison of change detection was followed to calculate transformation of water and agriculture in the study area. About 32830 hectare lands were extracted as waterlogged areas, which is 13% of the total land. Moreover, agriculture has been decreased while water bodies have upward trend. In this analysis, a multi-regression analysis was performed using Upazila wise water-logged as independent variable and Upazila wise damaged agriculture lands as dependent variable. This result shows a strong correlation between waterlogged and damaged areas, which was 93% at 95% confidence level with P value < 0.5. The overall accuracy assessment for water and agriculture were 92%, 91% and 95% in 1972, 1989 and 2014 respectively.