Abstract: Infection Prevention and Control (IPC) practices are kin practices and essential to excellence health care setting. It attends to issues associated to and from staff to patient or among staff. An infection Prevention and Control practice is something we cannot do without if we want to ensure a safe health delivery services and limit the spread of infections in the health-care setting or /and the community thereby, minimizing the risk of spreading infections. This research seeks to assess the perception of healthcare workers on IPC practices in two hospitals in Bo City.