The 2014 outbreak of Ebola Virus Disease is one of the zoonotic diseases that become health security threat for international community. It affected Guinea, Liberia, Sierra Leone, Nigeria, Senegal and Mali in West Africa and also USA and Spain outside of Africa. However, in Africa, Nigeria and Senegal securitized it successfully, but others not potentially contained it in time. This paper will be evaluated theory of securitization based on the Nigerian approach and highlighting the lessons that others affected countries could learn from the Nigerian approach and how to protect in the future. In light of this understanding, the paper will be discussed the military and nonmilitary issues of security studies, the Nigerian situation and history of Ebola as background; Ebola as health security threat, the Nigerian approach, the Copenhagen Schools theory of securitization, the Nigerian securitization framework and major lessons.