Abstract: Epidemiological surveillance of antimicrobial resistance is indispensable for empirically treating infections, implementing resistance, control measures and preventing the spread of antimicrobial resistant micro-organisms. Crude extracts from oven-dried pawpaw (Carica papaya) and pineapple (Ananas comosus) were tested against Staphylococcus aureus, Pseudomonas aureginosa, Escherichia coli and Streptococcus pneumonia. Even though, these test bacteria showed multidrug resistance against controlled conventional antibiotics, it was observed that the extract from C. papaya showed the highest potency at a concentration of 1.00g/ml on all the test bacteria, the efficacy of A. comosus was also pronounced against all the bacteria at the same concentration. The sensitivity of P. aeruginosa and Staph aureus were not significantly different (p≤ 0.05) at all concentrations of A. comosus extract, except at the concentration of 0.4g/ml and the sensitivity of all the test organisms were not significantly different at a concentration of 0.8g/ml. The sensitivity of all the test organisms at different concentrations of C. papaya extract varied significantly (p≤ 0.05), though E. coli and Strept pneumonia were not significantly different at a concentration of 0.2g/ml. The efficacy of fruits in therapy against diseases or infections from which these bacteria were isolated cannot be underestimated.