Abstract: This proposed system explains the wireless body sensor network based on ZigBee technology and GSM Platform. It is mainly used for collection and transmitting the various monitoring information or physiological parameters using Temperature Sensor, Heart Beat Sensor, Blood Presser, and ECG about the patients in hospitals or in their homes to an assigned medical doctor or practitioner. Here the physiological parameters or conditions of the subjects or the patients are monitored by sensors and the output of these sensors is transmitted via Zigbee-GSM communication medium and the same has to be sent to the remote wireless monitor for acquiring the observed patient’s physiological signal. The measured signal is sent to a PC, or mobile phone through the wireless transmission. The first procedure of the system is that the wireless sensors are used to measure Heart rate, temperature, blood pressure, and ECG waveform monitoring from human body using Zigbee. The measured signal is sent to the PC or mobile phone via the RS-232 serial port communication interface.