Abstract: Human immunodeficiency (HIV) and hepatitis B virus (HBV) are both of great concern in Nigeria. This study was conducted to understand the HIV and HBV prevalence among students and staff at the University of Jos (Jos, Nigeria) through a medical outreach program in which free screening was offered to voluntary participants at the university. Serum samples from 180 individuals were assayed for the presence of HBV surface antigen, HIV-1 p24 antigen, and HIV-1/2 antibodies. HIV prevalence was 3.88% and HBV prevalence was 7.22%. In sum, the prevalence of HBV and HIV among young Nigerian adults reflects the need for establishment of clear health policy for this risk group.