Abstract: Medicinal plants serve as important sources of pharmaceutical, cosmetic and traditional medicine. Natural products continue to play a significant role in drug discovery and development. Bioactive compounds, which naturally occurs in medicinal plants, such as antioxidants, play a vital role in scavenging free radicals. The purpose of this study was to evaluate preliminary phytochemicals, total phenolic content, total flavonoid content, antioxidants, and alpha (α)-amylase potential on selected South African plant extracts.