Abstract: Diabetes is recognized as a growing public health problem in the world and in Rwanda. One of the critical inputs to the strategies for combating this disease is to create attitudes and build knowledge about it within a population. This study aimed to find out Knowledge and Attitude towards Diabetes Mellitus among Type 2 Diabetes patients attending Biryogo Health centre. A cross sectional study that involved randomly selected 103 diabetes mellitus type 2 patients was conducted. The results revealed that the level of knowledge was good for the participants. However this knowledge is not translated into desired attitude. Statistically significant demographic characteristics associated with diabetes knowledge level indicator developed in the course of the study were gender (p<0.05) and duration of diabetes (p<0.01). It was further found out that significant variables associated with diabetes attitude level were respondent’s education level (p<0.05) and duration of diabetes (p<0.05).The fin