Abstract: Floods are one of the extreme disaster events which result in widespread social disruption, trauma, and extensive property damage, loss of life and social economic loss. Several humanitarian organizations including KRCS, USAID, CARE, Handicap International, JICA and OXFAM have always come in handy to help the victims through various interventions. The purpose of the study was to investigate socio-economic factors affecting response to floods by humanitarian organizations in Lower Kano Plain of Nyando Sub-County, Kenya. The sample sizes for the study were, chief, and 8 CBO chairpersons and 388 household heads. Combination of simple and stratified random sampling technique was used to select respondents, while purposive sampling techniques was used to select area chief and 8 CBO chairpersons.