Khalida Parveen, Manzoor Ahmad Malik, Farooq Ahmad Itoo, and Zahoor Ahmad Shah
Oral pregabalin premedication adequately sedates the patient and haemodynamic pressor response of airway instrumentation was attenuated Material and methods: The study was designed as a prospective randomized, double-blinded,placebo controlled study, which included 120 normotensive adult patients aged 24-56years of both genders,scheduled for elective surgery under general anaesthesia with ASA physical status I & II were allocated for the study.This study was done in the department of anaesthesia, and critical care,Sher-i-Kashmir institute of medical science, Srinager( J &K) after obtaining approval from ethical committee,a written informed consent was taken from the patients for participation in this study.Results: Systolic blood pressure increased maximally in group I(P0) and group II(P75) 1min after direct laryngoscopy and endotracheal intubation from baseline (32.1% from baseline).It gradually decreased to near baseline values over 10 minutes.In groupIII (P150) maximum rise in blood pressure was 11.1% from baseline.Among these only pregabalin 150mg attenuated the rise in blood pressure following laryngoscopy(p-value=0.001).
Khalida Parveen, Manzoor Ahmad Malik, Farooq Ahmad Itoo, and Zahoor Ahmad Shah (2017); The Effectiveness of Oral Pregabalin in Attenuation of Systolic Blood Pressure and Heart rate due to airway instrumentation During General Anaesthesia.A Dose Response Study ;
Int J Sci Res Publ 7(10) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-1017.php?rp=P706891