Abstract: In the last few decades, it has been recognized that Soil Structure Interaction (SSI) altered the response characteristics of a structural system because of massive and stiff nature of structure and, often, soil softness. The present study makes an attempt to show the response of a structure in earthquake analysis by considering the effect of soil structure interaction. For superstructure G+7 simple square building is considered for seismic analysis. A study has to be carried out for buildings with the same geometry found on varying soil types over pile- grid foundation. An attempt has to be made to find the deformations under seismic loading in the structure and pile- grid foundation by incorporating the effect of soil-structure interaction which is further compared with those of fixed base condition. Influence of variation of the parameters such as, different soil conditions and number of stories are also considered for which the buildings are modelled by alternate approaches, namely, (1) bare frame with fixed supports, (2) bare frame with supports accounting for soil-flexibility using Ansys 14.5.