Abstract: Enteral feeding formula has shown to be beneficial in cancer patients, where otherwise the gut is efficacious in digestion and absorption of food but oral intake is not possible due to anorexia, tumor burden, and side effects of treatments. Long term enteral feeding programmed with extreme use of commercially available expensive enteral formula all pose a requirement of development of an Low Cost Enteral Formula (LCEF). Aim: to formulate low cost enteral formula and analyze its nutritional composition in comparison to other commercial formulae available in market. Material and Methods used: the low cost enteral formula using indigenous grains was developed by undergoing to different procedures. The formula obtained was then standardized along with commonly used commercial nutraceutical products. Both these were evaluated for nutritional value and cost. A study was conducted wherein LCEF was supplemented to post surgery head and neck cases in comparison to control group who were fed a commercially available nutraceutical supplement. A pre and post intervention comparative study was conducted including various parameters- weight, MUAC, BMI, Serum Protein, Serum Albumin and hemoglobin. Results: the low cost enteral formula developed, provided similar macro and micronutrients with low cost as compared to commercially available formulas. The results as indicated by various parameters showed that the experimental and control group had similar results. Patients also had good tolerance for the feed. Conclusion: LCEF can be used as an enteral formula in exchange to other commercial nutraceutical supplements available because of its cost effectiveness, similar nutritional content, easy to prepare at home, with nutrients in natural food form, making adaptation to normal foods easy and thus providing emotional comfort to patients.