Abstract: Depression as a disease is rampart to people regardless of sex, class, position in the community and it is common to old people and adult. In order to prevent and reduce the rate of depression, this research give work has born. It was born out of a mindset that is ready to the economy everything the community had given. This paper examined the effect of hormone related drug in relieving depression and 3 level of drug was administered, a placebo treatment, a moderate dose and a high dose. The data was collected from Ekiti-State Police Clinic, the data are in quarters for the year 2012 and it is a secondary data. The aim of the paper is to find out whether gender or level of dose of drug administered has anything to do with the relieving of depression. Based on the analysis it can be seen that either high level of dose, placebo treatment or moderate dose we obtain averagely the same of outcome but there other method used for treatment of depression that will not make the drug to work. And also gender does not have anything to do with the relive of depression.