Abstract: Adolescence is a demographic force and its sexual and reproductive health has become an area of focus for many national governments in both developed and developing countries. This study aimed to identify reproductive health issues among adolescents in Nyanza District, in Rwanda. To meet this objective, a cross sectional study was carried out, stratified random sampling technique was used. The study participants were 298 adolescents. Unplanned pregnancy was mentioned by (27%), Abortion was mentioned by (25%) of participants, STIs and HIV/AIDs (24%). Condom use was reported by 18.9% among males and 6.0% among females. Early marriage 35.5%, knowledge about body changes in puberty (24.8%). Alcohol and other substance abuse (56.4%), sex abuse and exploitation (3.0%) among male and (9.0%) among female. School dropout (70.4%). Health facilities with supplies, strengthening, and promoting sexual education in and out of school, and condom and contraception use among adolescents should be intensified.