Abstract: To assess pediatric nurse's knowledge about managing of Respiratory Distress Syndrome, to determine the effectiveness of the educational program through comparing nurse's knowledge in pre and post education program. And to find out the association between nurse's knowledge and their demographic data.MethodologyA pre-test and post-test quasi-experimental study design was carried out in order to evaluate theeffectiveness of an educational program on nurse's knowledge about management of newborn babies with Respiratory Distress Syndrome (RDS) in pediatric units at Al Diwaniyah teaching Hospital. The study began from September 20th 2016 to August 6th, 2017.A quasi-experimental design was carried out from March 12th to June 22nd, 2017.