Abstract: Assessment of mineral nutrient and proximate contents of Gongronema latifolia Benth was conducted in the derived savanna and rainforest zones of Nigeria. Ogoja, in Cross River State, and Abak, in Akwa Ibom State were choosen to represent the derived savanna and rainforest zones, respectively. Five (5) sampling units were choosen for collection of samples in each experimental site. Soil and leaf (G. latifolia) samples were collected from the study area. The contents of N, Na, Mg, and K in soils of rainforest zone were significantly (P < 0.05) higher than those of the derived savanna zone. The contents of K, Mg, Na, P, Cu, and Zn in leaf samples of the test crop in rainforest zone were significantly (P < 0.05) higher than those in the derived savanna zone. Similarly, the moisture, crude fat, ash and carbohydrate content in leaf of the test crop were comparatively (P < 0.05) higher than those of the derived savanna zones. This study suggests that the nutritional potentials of this species is influenced by ecological factors, hence, can be enhanced by using appropriate cultural practices and environmental conditions for its growth and development.