Abstract: Climate change remains a major challenge to Homa Bay County whose main sources of livelihoods include fishing and fish trade, fish processing and agricultural production. The objectives of this study were to establish the potential of households to adapt to climate change and to evaluate adaptation strategies to climate change impacts in Homa Bay County, Kenya. The study adopted cross-sectional survey and evaluation research designs. Both qualitative and quantitative data were collected from male and female farmers in Homa Bay County. A sample size of 384 farmers was randomly selected and used in the study. Quantitative data analyses were done using SPSS package. The results reveal that there exist potential for households to adapt to the changing climate in the study area. The major factors influencing adaptation include lack of economic resources; availability and access to technology; levels of information and skills; social infrastructure; role of institutions; and equity in resource allocation. The local community response strategies include tree planting 335 (95%), planting more vegetation 245 (70%), changing and or diversifying crops 153(43.5%), rehabilitation of water storage structures 119 (34%) and paying more attention to weather forecasts. The main barriers to these coping strategies include lack of knowledge 207 (54%), insufficient funds 150 (39%) and lack of tools 27 (7%). The study proposes the use of short, medium and long-term adaptation measures for sustainability. These findings are important in strengthening local adaptation strategies and developing suitable policy frameworks to address the issue of resource mobilization in Homa Bay County.