Abstract: This cross-sectional study was conducted in 50 liver disease patients and 50 non-liver disease patients, who were examined clinically and confirmed sonographically for liver involvement. All the parameters of Conventional Liver Function Tests (CLFTs) including serum Bilirubin, SGPT, SGOT, ALP, Total Protein and Albumin were estimated and compared in liver disease and non-liver disease patients. Data was analyzed by non-parametric Mann-Whitney test and statistical significance was calculated. It showed that serum bilirubin was highly significant (p<0.001), while SGPT and SGOT were raised in liver disease patients, but they were not statistically significant (p>0.05). So none of the individual test can predict the liver disease and at times it can lead to a confusing situation between liver disease and non-liver disease. The present study concludes that more sensitive and specific parameters are needed to correctly diagnose liver disease and at the same time it must rule out non-liver diseases.