Abstract: A new simple, rapid, accurate, sensitive and precise spectrophotometric method for the determination of trifluoperazine hydrochloride in bulk and capsule dosage form .pharmaceutical formulations is described. The method is based on the simple solubility of trifluoperazine hydrochloride in methanol. The absorbance maximum of trifluoperazine hydrochloride measured at wave length 265 nm. The drug obeys Beer’s Law in the concentration range 2-45 μg/ml employed for this method. Accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The method is easily be employed in the laboratory for the routine estimation of drug and it’s extended to the analysis of trifluoperazine hydrochloride in pharmaceutical formulations.