Abstract: Diphtheria is one of the infectious diseases that can be prevented by immunization which was still suffered 954 people with a mortality rate of 4.61%. West Java Province is one of the provinces with the second largest number of sufferers in Indonesia. Many statistical tests but do not include spatial elements in the analysis. The purpose of this study was to find out the spatial relationship between diphtheria incidence and the relationship factors in DPT immunization coverage. This study was cross-sectional with spatial regression data analysis approach were used 2017 of West Java Province health profile’s data and reports from the Central Statistics Agency of Indonesia.