Abstract: Endophytic microbes are considered as an outstanding source of bioactive natural products because there are so many of them occupying millions of unique biological niches growing in different types of environment. Plants infected with endophytes are often healthier than endophytes free ones. These endophytes are the prominent source of secondary metabolites similar to the plant tissue on which these endophytes are grown. The present study illustrates about the isolation and screening of endophytes from aerial parts (leaves and stems) of Mentha piperita plant. A total of 4 different bacterial endophytes were isolated from leaves which were marked as L1, L2, L3 and L4 while only 2 different types of bacterial endophytic cultures were isolated from stems of the plant which were marked as S1 and S2.