Abstract: Introduction: The important determinant of treatment success is adherence to recommended medication and it is one of the factors which plays a major role between process of disease and its prognosis. Compliance of patients depends on many factors such as resource limitations, cost of the treatments, patient’s beliefs.Diabetes mellitus is a metabolic disorder. There are two types which are type 1 diabetes and type 2 diabetes.In patients with diabetes, non-adherence can lead to many serious complications. Primary goal in management of diabetes is to keep the blood glucose levels stable. Majority of diabetic patients are ineffectual in controlling their blood glucose levels with modifications in diet ,exercise and required medication. The aim of this study was to assess the compliance of diabetic patients to prescribed clinical regimen and factors affecting it.