Abstract: Guillain-Barré syndrome (GBS), though associated with progressive motor weakness and areflexia, there have been case reports of GBS presenting as hyperreflexia and maintained reflexes. Early detection and treatment is of paramount importance as delay in diagnosis portends a poor prognosis to the patient. There is clear evidence of an association of an antecedent infectious disease associated with the development of GBS, therefore if proper diagnostic studies are not considered early in the course of treatment, the potential antecedent etiology may remain elusive. Here we report an atypical case of GBS with hyperreflexia precipitated by Lyme’s disease.